Biography
Dr. Toedt is an accomplished Physical Biochemist with expertise in advanced biophysical characterization of macromolecules. Dr. Toedt was a Post-Doctoral research scientist at the Center for Advanced Research and Biotechnology in conjunctions with the National Institute of Standards and Technology (NIST). He earned a M.S. in Biotechnology and Ph.D. in Biophysics at the University of Connecticut. His thesis centered on biophysical characterization of protein structure and molecular interactions at the National Institute of Analytical Ultracentrifugation.
Research Interests
- Biophysical Characterization of Macromolecules
Teaching Interests
- Biochemistry
- Physical Biochemistry
- Physical Biochemistry Techniques
Publications
Teplyakov A, Obmolova G, Toedt J, Galperin MY, Gilliland GL. Crystal structure of the bacterial YhcH protein indicates a role in sialic acid catabolism. J Bacteriol. (2005) 187(16):5520-7.
Lim, K., Zhang, H., Toedt, J., Tempcyzk, A., Krajewski, W., Howard, A., Eisenstein, E., Herzberg, O. Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): A cofactor bound at a site formed by a knot. Proteins. (2003) 51(1): 56-67.
Lim K, Tempczyk A, Bonander N, Toedt J, Howard A, Eisenstein E, Herzberg O. A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Haemophilus influenzae HI0670. J Biol Chem. (2003) 278(15): 13496-13502.
Michael A. Tangrea, Patrick Alexander, Philip N. Bryon, Edward Eisenstein, John Toedt, and John Orban. Stability and Global Fold of the Mouse Prohormone Convertase 1 Pro-Domain. Biochemistry (2001) 40:5488-5495.
John M. Toedt, Emory H. Braswell, Todd M. Schuster, David Yphantis, Zenobia F. Taraporewala, and James N. Culver.Biophysical Characterization of a Designed TMV Coat Protein Mutant, R46G, That Elicits a Moderate Hypersensitivity Response in N. sylvestris. Protein Science (1999) 8:261-270.
