John M. Toedt

Professor Professor

Biochemistry Program Coordinator


   Office:  Science Building Room 452

   Phone:  860-465-0182

   Fax:      860-465-5213



       B.S.   BioChemistry, American International College

       M.S.  BioTechnology, University of Connecticut

       Ph.D. BioPhysics, University of Connecticut




CHE 205 Chemistry of Life w/Lab

CHE 316 Biochemistry Lecture I

CHE 317 Biochemistry Lab I

CHE 323 Physical Biochemistry

CHE 410 Physical Biochemistry Techniques

CHE 450 The Biochemistry Profession




John Toedt Theodore Gray’s Elements Vault Treasures of the Periodic Table with Removable Archival Documents and Real Element Samples Review, American Biology Teacher v. 74, no. 4 April (2012)

ALKALINE PHOSPHATASE EXPRESSION STUDY. Nicole Bates, John M. Toedt ECSU undergraduate Research symposium April 2009.


Chemical Composition of Everyday Products. John M. Toedt, Darrell Koza, Kathleen A. Van Cleef-Toedt. Greenwood Publishing (2005)


Toedt, John M. Understanding Life through Chemistry: New Bachelors of Science program in Biochemistry offered at Eastern Connecticut State University. NEACT Newsletter Volume 58 No. 3 March 2005


Lim, K., Zhang, H., Toedt, J., Tempcyzk, A., Krajewski, W., Howard, A., Eisenstein, E., Herzberg, O. Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): A cofactor bound at a site formed by a knot. Proteins. (2003) 51(1): 56-67.


Lim K, Tempczyk A, Bonander N, Toedt J, Howard A, Eisenstein E, Herzberg O. A catalytic mechanism for D-Tyr-tRNATyr deacylase based on the crystal structure of Haemophilus influenzae HI0670. J Biol Chem. (2003) 278(15): 13496-13502.     


Lim K, Tempczyk A, Parsons JF, Bonander N, Toedt J, Kelman Z, Howard A, Eisenstein E, Herzberg O.Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein of unknown function coexpressed with the recombinational DNA repair protein RecR. Proteins. (2003) 50(2): 375-379.


Gilliland GL, Teplyakov A, Obmolova G, Tordova M, Thanki N, Ladner J, Herzberg O, Lim K, Zhang H, Huang K, Li Z, Tempczyk A, Krajewski W, Parsons L, Yeh DC, Orban J, Howard AJ, Eisenstein E, F Parsons J, Bonander N, Fisher KE, Toedt J, Reddy P, Rao CV, Melamud E, Moult J. Assisting Functional Assignment for Hypothetical Heamophilus influenzae Gene Products through Structural Genomics. Curr Drug Targets Infect Disord (2002) 2(4): 339-53. 


Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: Activation by conformational transition. Lehmann C, Lim K, Toedt J, Krajewski W, Howard A, Eisenstein E, Herzberg O. PROTEINS:Structure, Function, and Genetics (2002) 49(1):135-138.


Crystal structure of Yeco from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine . Kap Lim, Hong Zhang, Aleksandra Tempczyk, Nicklas Bonander, John Toedt, Andrew Howard, Edward Eisenstein, Osnat Herzberg. PROTEINS:Structure, Function, and Genetics (2001) 45:397-407


Stability and Global Fold of the Mouse Prohormone Convertase 1 Pro-Domain. Michael A. Tangrea, Patrick Alexander, Philip N. Bryon, Edward Eisenstein, John Toedt, and John Orban. Biochemistry (2001) 40:5488-5495.


Hypothetical Proteins from Haemophilus Influenzae: Two New Structures Implying Methyltransferase Function. Kap Lim, Hong Zhang, Alexandra Tempczyk, Nicklas Bonander, John Toedt, Andrew J. Howard, Edward Eisenstein, and Osnat Herzberg.  Center for Advanced Research in Biotechnology, Rockville, Maryland  20850.  Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois  60439  American Crystallographic Association meeting July 2000


Biophysical Characterization of a Designed TMV Coat Protein Mutant, R46G, That Elicits a Moderate Hypersensitivity Response in N. sylvestris. John M. Toedt, Emory H. Braswell, Todd M. Schuster, David Yphantis, Zenobia F. Taraporewala, and James N. Culver. Protein Science (1999) 8:261-270.


New Revolutions In Analytical Ultracentrifugation. Todd M. Schuster & John M. Toedt. Current Opinions In Structural Biology Vol. 6 No 5 (1996) 650 – 658.


   Professional Society Memberships:

  • American Chemical Society (ACS)
  • American Association for the Advancement of Science (AAAS)
  • Reversible Associations in Structural and Molecular Biology (RASMB)
  • The New England Association of Chemistry Teachers (NEACT)